Bioactive Small Molecules
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Filtered Search Results
Apexbio Technology LLC GSK126 1346574-57-9 50mg
GSK126 (CAS 1346574-57-9) is a small-molecule inhibitor of EZH2 exhibiting a Ki value of 93 pM EZH2 a catalytic subunit of polycomb repressive complex 2 (PRC2) often exhibits increased expression or activating mutations in various cancers correlating with tumor progression and poorer prognosis GSK126 binds preferentially to activated EZH2/PRC2 complexes and shows enhanced sensitivity toward lymphoma cell lines harboring EZH2 mutations (Y641N Y641F A677G) It demonstrates growth-inhibitory activity in small cell lung cancer (DMS53 LU30 H209) cells and ovarian cancer cells restoring ARNTL expression and increasing cisplatin sensitivity In mouse xenograft tumor models with EZH2-mutant lymphoma intermittent dosing of GSK126 suppresses tumor growth highlighting potential therapeutic relevance in oncology research
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Medchemexpress LLC T-PA Human HEK293 5ug
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Recombinant human tissue plasminogen activator (tPA) produced in HEK293 cells with a C-terminal His tag. Supplied at high purity and suitable for biochemical and fibrinolysis assays, the glycosylated protein has an apparent molecular weight of approximately 62-72 kDa and is provided in a 5 μg quantity for research applications.
- Expressed in HEK293 cells.
- Contains a C-terminal His tag for affinity purification.
- High purity suitable for biochemical assays (~98%).
- Glycosylated protein with apparent molecular weight ~62-72 kDa.
- Supplied as a 5 μg quantity for small-scale studies.
- For research use only.
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Cayman Chemical Antagonist G (trifluoroacetate salt), Purity: ≥98%, 5 mg
A neuropeptide antagonist; inhibits binding of vasopressin to rat liver or Swiss 3T3 membranes (IC50s = 3.5 and 2.2 µM, respectively); inhibits vasopressin-induced production of inositol phosphate in Swiss 3T3 fibroblasts (IC50 = 1 µM); induces apoptosis and the production of ROS in NCI H69 cells at 50 µM; reduces tumor growth in an NCI H69 mouse xenograft model at 45 µg/g
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Medchemexpress LLC Dihydrochalcone 10g | 1083-30-3 | 10 G
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Dihydrochalcone is a small-molecule research reagent reported to inhibit Aβ aggregation and to penetrate the blood-brain barrier. Supplied as a solid with high reported purity, it is intended for biochemical assays and neuroscience research.
- High reported purity: 99.87%.
- Molecular weight 210.27 g/mol.
- Chemical formula C15H14O.
- Available in laboratory pack sizes including 10 g.
- Suitable for Aβ aggregation and biochemical assays.
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Medchemexpress LLC 4-(3,5-difluoro-4-hydroxybenzylidene)-1-methyl-5-oxo-4,5-dihydro-1H-imidazole-2-carbaldehyde oxime | 1420815-34-4 | 99.8% | 281.21 g·mol-1 | C12H9F2N3O3 | 5 MG
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DFHO is a fluorogenic small molecule that is activated by binding to the Corn RNA aptamer, converting into a fluorescent form and enabling RNA imaging in living cells. It exhibits low background fluorescence and low cytotoxicity, and is supplied at high purity for research applications.
- Binds the Corn RNA aptamer and becomes fluorescent (Kd ≈ 70 nM).
- Enables live-cell RNA imaging via aptamer-activated fluorescence.
- Low background fluorescence and low cytotoxicity in cellular assays.
- High purity suitable for biochemical and imaging experiments.
- Supplied in small-mass pack sizes for research use.
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Cayman Chemical Alda-1, Purity: ≥98%, CAS: 349438-38-6, 50 mg
A selective ALDH2 agonist; enhances wild-type ALDH2*1 and East Asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (2.1-, 2.2-, and 11-fold increase in Vmax of 20 µg homozygous WT, heterozygous WT/mutant, and homozygous mutant tetramer, respectively, at 100 µM); has no effect on alcohol dehydrogenase 1, cytosolic ALDH1, or mitochondrial ALDH5; protects against ex vivo ischemic tissue damage to excised rat hearts; reduces infarct size in anesthetized live rats
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Cayman Chemical CRT0066854, Purity: ≥98%, CAS: 1438881-19-6, 10 mg
A PKCι and PKCζ inhibitor (IC50s = 132 and 639 nM, respectively); an inhibitor of ROCK2 (IC50 = 620 nM); is selective for PKCι, PKCζ, and ROCK2 over typical PKCs and 98 other kinases in a panel at 1 µM; decreases viability of A549 lung carcinoma cells (IC50 = 3.47 µM); decreases colony formation in HeLa cells by 65% at 1 µM; impairs lumen formation in MDCK cells in a Matrigel™ assay and migration of NRK-49F cells in a wound assay
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Cayman Chemical Aucubin, Purity: ≥98%, CAS: 479-98-1, 50 mg
An iridoid glycoside with diverse biological activities; dose-dependently inhibits the IgE-stimulated secretion of IL-6 and TNF-α by RBL-2H3 mast cells (IC50s = 0.19 and 0.1 μg/ml, respectively); reduces UVB-induced expression of MMP-1 by 57% in HS68 cells at 0.01 μg/ml; dose-dependently reduces ROS and MDA levels in HS68 cells at 0.01-1 μg/ml; decreases the breathing frequency, increases lung dynamic compliance, alleviates parenchymal fibrotic changes, and reduces expression of TGF-β1 and α-SMA in a mouse model of bleomycin-induced pulmonary fibrosis at 5 mg/kg; reduces blood glucose levels, lipid peroxidation in the liver and kidneys, the number of errors made in a Y-maze, and enhances neuronal survival in rats with streptozotocin-induced diabetes at 5 mg/kg
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Enzo Life Sciences Ac-YVAD-CMK (5mg). CAS: 178603-78-6
Irreversible, cell permeable inhibitor of caspase-1. Also inhibits caspase-4. Inhibits Fas-mediated apoptosis. Alternative name: Caspase-1 inhibitor (chloromethylketone). Formula: C24H33N4O8Cl. MW: 541.0. Purity: ≥96% (HPLC). Solubility: Soluble in DMSO (50mg/ml). Long Term Storage: -20°C.
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Selleck Chemical LLC BI-3802
BI-3802 is a highly potent oncogenic transcription factor BCL6 degrader with strong de-repression of target genes anti-proliferative effects BI-3802 inhibits the BTB domain of BCL6 with IC50 of 3 nM BI-3802 exhibits antitumor activity
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Selleck Chemical LLC Isofraxidin S9240-1MG
Isofraxidin (6 8-Dimethoxyumbelliferone) a bioactive coumarin compound isolated from the functional foods Siberian ginseng and Apium graveolens is an anti-bacterial anti-oxidant and anti-inflammatory agent
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Selleck Chemical LLC T-5224 S8966-1G
T-5224 is a selective inhibitor of transcription factor c-Fos/activator protein (AP)-1 with anti-inflammatory effects T-5224 specifically inhibits the DNA binding activity of c-Fos/c-Jun and the IL-1 -induced up-regulation of Mmp-3 Mmp-13 and Adamts-5 transcription
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Selleck Chemical LLC AZ304 S8755-5MG
AZ304 is a synthetic inhibitor designed to interact with the ATP-binding site of wild type and V600E mutant BRAF with IC50 values of 79 nM and 38 nM respectively It also inhibits CRAF p38 and CSF1R at sub 100 nM potencies
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Selleck Chemical LLC Elraglusib S9602-25MG
Elraglusib(9-ING-41) is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with antitumor activity 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3
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Selleck Chemical LLC C75 trans S8915-10MM/1ML
C75 trans (trans-C75 ( )-C75) is a novel potent synthetic inhibitor of fatty acid synthase (FAS/FASN) with IC50 of 35 M and 50 M in clonogenic assays and spheroid growth assay respectively C75 is used as a tool for studying fatty acid synthesis in metabolic disorders and cancer
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